18视频高清免费观看

中西医药Chinese and Western Medicine
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雷贝拉唑钠肠溶胶囊(济诺)

【成 份】:雷贝拉唑钠 化学名称:2-[[[4-(3-甲氧基丙氧基)-3-甲基-2-吡啶基]甲基]亚磺酰基]-1H-苯并咪唑钠。
【性 状】:本品为肠溶胶囊,内容物为类白色或微黄色颗粒或粉末。
【功能主治】:

  1、活动性十二指肠溃疡;

  2、良性活动性胃溃疡;
  3、伴有临床症状的侵蚀性或溃疡性的胃-食管反流征(GERD);
  4、与适当的抗生素合用,可根治幽门螺旋杆菌阳性的十二指肠溃疡;
  5、侵蚀性或溃疡性胃-食管反流征的维持期治疗,目前疗程超过12个月的药效尚未进行评估。




【规    格】(1)   10mg  (2) 20mg

【yongfayongliang】

    benpinbunengjujiaohuoyasuifuyong,yingzhenglitunfu。

18视频高清免费观看     1、chengnianren/laonianhuanzhedeyongyao:

    a、huodongxingshierzhichangkuiyanghehuodongxingliangxingweikuiyanghuanzhe:yici20mg,yiri1ci,chenfu。

         daduoshuhuodongxingshierzhichangkuiyanghuanzhezaiyongyao4zhouhouquanyu。danyou2%dehuanzhehaixuyaojixuyongyao4zhoucainengquanyu。

         yixieshierzhichangkuiyanghuanzheyici10mg,yiri1cidezhiliaoliangjiyoufanying。

        daduoshuhuodongxingliangxingweikuiyangxuzaiyongyao6zhouhouquanyu。danyou9%dehuanzhehaixujixuyongyao6zhoucaikequanyu。

    b、qinshixinghuokuiyangxingdewei-shiguanfanliuzheng(gerd)huanzhe:yici20mg,yiri1ci,liaochengwei4~8zhou。

18视频高清免费观看     c、wei-shiguanfanliuzhengdezhangqizhiliaofangan(gerd)deweichizhiliao:liaochengwei12geyue,weichizhiliaoliangweiyici10mghuo20mg,yiri1ci。yixiehuanzheduiyiri10mgdeweichizhiliaoliangjiyoufanying。

18视频高清免费观看     d、youmenluoxuanganjundegenzhixingzhiliao:

         yushidangdekangshengsuheyong,kegenzhiyoumenluoxuanganjunyangxingdeshierzhichangkuiyang。

18视频高清免费观看          benpinyingzaizaochen、canqianfuyong,jinguanyongyaoshijianjisheshiduileibeilazuonayaoxiaowuyingxiang,dancizhongjiyaofangshigengyouliyuzhiliaodejinxing。

    2、ganshengongnengbuquanhuanzhedeyongyao:

18视频高清免费观看     ganshengongnengbuquanhuanzhezaiyongyaoguochengzhongwuxujinxingjiliangdiaojie。danzaiduiyouyanzhongdegangongnengbuquanhuanzheyongyaoshi,yingcanjian“buliangfanyingjizhuyishixiang”。

【buliangfanying】

18视频高清免费观看      1.oujian(buliangfanyingfashenglvzai0.1%?5%):guangminxingfanying、toutong、exin、outu、bianmi、fuzhang、fuxie、pizhen、qianmazhen;hongxibaojianshao、baixibaojianshao、baixibaozengduo、shisuanxinglixibaozengduo、shizhongxinglixibaozengduo、linbaxibaojianshao;alt、ast、alp、γ-gtp、ldh、zongdanhongsu、zongdanguchun、bunshenggao;danbainiaodengbuliangfanying。

18视频高清免费观看      2. hanjian(buliangfanyingfashenglvzai<0.1%):xiuke、xinji、xindongguohuan、xiafutong、xiaohuabuliang、xiongtong、jitong、shilizhangai、xuanyun、shimian、kunjuan、juandaigan、wolidixia、sizhifali、ganjuechidun、kouchibuqing、butaipanshan、rongxuexingpinxuedeng。ciwaiguowai1liyouganxingnaozhengjiwangshideganyinghuahuanzhechuxianlejingshencuoluan、shibianlisangshiheshishui。

【jin    ji】

     duileibeilazuona、benbingmizuodaixiewuhuofuliaoguominzhejinyong。

【zhuyishixiang】

     1. yongbenpinkaishizhiliaozhiqianyingpaichucunzaiaizhengdekenengxing。jinguanzainianlinghexingbiepipeideqingzhongduganzangsunshanghuanzheyuzhengchangzhededuizhaoyanjiuzhong,weijiandaomingxianyuyaowuxiangguandeanquanwenti,danshizhongdugansunshanghuanzhechucishiyongbenpinzhiliaoshi,yishengjianyiyaotebiezhuyi。

     2. fuyongbenpinshi,yingdingqijinxingxueyejianchajixueyeshenghuaxue(ruganmeijiancha),faxianyichang,jitingzhiyongyao,bingjinxingjishichuli。

     3. gangongnengsunshangdehuanzheshenyong。

【yunfujiburuqifunvyongyao】

     1. duiyuyunfuhuoyoukenengrenshendefunv,zhiyouzaiqizhiliaoyouyixingdayuweixianxingdeqiantixiafangkeshiyong。

     2. benpinkenengtongguoruzhifenmi,gubimianyongyuburuqifunv,budeyierbixuyongyaoshi,zeyingzantingjiyingerburu。

【ertongyongyao】

     muqianshangwuertongfuyongbenpindeanquanxingheyouxiaoxingziliao。

【laonianyongyao】

18视频高清免费观看      linchuangyanjiubiaoming,weijian65suiyishanghuanzheyunianqinghuanzhezailiaoxiaoyuanquanxingfangmianyouchayi,danbupaichumouxielaonianhuanzhedeminganxinggengqiang。youyubenyaozhuyaozaiganzangdaixie,erlaonianhuanzhegangongnengdixiazhejuduo,youshikechuxianbuliangfanying。yinci,dangchuxianxiaohuaxitongbuliangfanying(canzhao“buliangfanying”xiang)shi,yingjinshenjiyu,biyaoshiyingtingzhiyongyao。

【yaowuxianghuzuoyong】

18视频高清免费观看      leibeilazuonatongguoxibaosesup450(cyp450)daixiemeixitongjinxingdaixie。jiankangshiyanzheyanjiubiaoming,leibeilazuonalinchuangshangmeiyoumingxiandeyuqitadetongguocyp450xitongdaixiedeyaowuyouxianghuzuoyong。

18视频高清免费观看      leibeilazuonanenggouchanshengchixuxingdeyizhiweisuanfenmidezuoyong。youyuleibeilazuonashisuanduxiajiang,yinci,yuneixiexishouyuweiphzhiyouguandeyaowuyouxianghuzuoyong。liru,zhengchangshoushizheruguomeitiantongshifuyongtongkangzuoyu20mgleibeilazuona,huishitongkangzuodeshengwuliyongdujianshaodayue30%;tongshifuyongdigaoxin,huishidigaoxindeauchecmaxzhifenbiezengjia19%he29%。yinci,bingrenzaitongshifuyongshangshuyaowuheleibeilazuonashiyingjinxingjiance。leibeilazuonayukangsuanjitongshifuyongyijizaifuyongkangsuanji1xiaoshihouzaifuyongshi,leibeilazuonadepingjunxuejiangzhongnongduquxianxiamianjifenbiexiajiang8%he6%。benpindeleisiyaowuaomeilazuoyubentuoyingtongfuyoudaozhibentuoyingdaixiehuopaixieyanhuandebaogao。

【yaowuguoliang】

      wuyizhidetexiaojieduji。fuyongbenpinguoliangshi,yinganhuanzhedelinchuangzhengzhuanghetizheng,caiyongshidangdezhichiliaofa。

【yaoliduli】

      yaolizuoyong:

18视频高清免费观看       leibeilazuonaweibenbingmizuoleihuahewu,shidierdaizhizibengyizhiji,tongguoteyixingdiyizhiweibixibaoh+, k+-atpmeixitongerzuduanweisuanfenmidezuihoubuzhou。gaizuoyongchengjiliangyilaixing,bingkeshijichuweisuanfenmihecijizhuangtaixiadeweisuanfenmijunshouyizhi。benpinduidanjianhezuanh2shoutiwujiekangzuoyong。

18视频高清免费观看  duliyanjiu:

      yichuanduxing:benpinshushanghanshamenshijunhuifutubian(ames)shiyan、zhongguocangshuluanxibaojiyintushiyan、xiaoshulinbaliuxibaojiyintubianshiyanjieguojunchengyangxing;qiqujiajidaixiewuzaishiyanzhongyechengyangxing;benpintiwaicangshufeixibaoransetijibianshiyan、xiaoshuweiheshiyanhetinei、tiwaiganchengxuwaidnahecheng(uds)shiyanjieguojunweiyinxing。

shengzhiduxing:

      dashujingmaijiyuleibeilazuona50mg/kg/ri(xuejiangaucyueweihuanzhelinchuangtuijianjiliangshide13bei)hetujingmaijiyubenpin50mg/kg/ri(xuejiangaucyueweihuanzhelinchuangtuijianjiliangshide8bei),qishengyuliheshengzhixingweiweijianmingxianyichang,duidongwutaiziweijiansunshang。shangwuhuaiyunfunvjiyaodechongfenheyangeduizhaodelinchuangyanjiu,youyudongwushengzhiduxingbingbuzongnengyuceyaowuduirentideyingxiang,guhuaiyunqijianjinzaiqueshixuyaoshicainengshiyongbenpin。

18视频高清免费观看 dashuzairenshenhouqiheburuqijingkoujiyuleibeilazuona0.4g/kg/ri,kedaozhidongwutizhongzengzhangjianman。youyuxuduoyaowukejingruzhifenmi,qiekenengduiburuyingerchanshengdufuzuoyong,guyingkaolvyaowuduimuqindezhongyaoxing,juedingzaiciqijianshitingzhiburuhaishitingzhiyongyao。

zhiaixing:

      caiyongcd-1xiaoshujinxingle88/104zhoushiyan,leibeilazuonajingkoujiyaojilianggaoda0.1g/kg/rishiweibiaoxianchuzhongliufashenglvzengjia,cishixueyaonongduweihuanzhetuijianjiliangxiade1.6bei。caiyongsddashujinxinglejiyao104zhoudezhiaixingshiyanyanjiu,qizhongxiongxingdashukoufujiliang5,15,30,60mg/kg/ri,cixingdashukoufujiliang5,15,30,60he120mg/kg/ri,jieguosuoyoujiliangzuci、xiongdongwujunchuxianweichangshigexibaoyang(elc)zengsheng,cixingdongwusuoyoujiliangzudouchuxianweichangshigexibaoyang(elc)liangxingzhongliu。xiongxingdongwujishizaizuigaojiliangzu(xueyaonongduxiangdangyulinchuangtuijianjiliangxiade0.2bei)xia,yeweijianyuyaowuyouguandezhongliuchansheng。

【yaodaidonglixue】

18视频高清免费观看  jiankangchengniannanzizaikongfuqingkuangxiadancikoufubenji10mg、20mg、40mgshideyaodaidonglixuecanshuruxia:

      雷贝拉唑钠的血浆蛋白结合率约为97%,主要的代谢产物为硫醚(MI)和羧酸(M6)。 次要代谢物还有砜(M2)、乙基硫醚(M4)和硫醚氨酸(M5)。只有乙基代谢物(M3)具有少量抑制分泌的活性,但不存在于血浆中。该药90%主要随尿排出,其它代谢物随粪便排出。在需要血液透析的晚期稳定的肾衰患者体内(肌酐清除率 ≤5ml/min/1.73m2),雷贝拉唑钠的分布与在健康受试者体内的分布相似。此药用于老年患者时,药物清除率有所降低。当老年患者用雷贝拉唑钠20mg,一日1次,连续7日,出现血药浓度的曲线下面积加倍,血药浓度峰值相对于年轻健康受试者升高60%。另外,此药在体内无累积现象。

18视频高清免费观看 【zhu    zang】

      mifeng,zaiyinliang(buchaoguo20℃)ganzaochubaocun。

【bao    zhuang】

      juxianan/lv/julvyixilengchongyachengxinggutiyaoyongfuheyingpian、yaoyongbaozhuanglvbobaozhuang;julvyixi/jupianerlvyixigutiyaoyongfuheyingpian、yaoyongbaozhuanglvbobaozhuang

      1. 10mg:6li/ban,1ban/he,2ban/he,3ban/he;7li/ban,1ban/he,2ban/he,

      2. 20mg:6li/ban,1ban/he, 7li/ban,1ban/he。

【有 效 期】18个月

【执行标准】《中国药典》2015年版二部及检查项“水分”执行标准YBH09252004-2014Z

【pizhunwenhao】

18视频高清免费观看     (1)10mg:guoyaozhunzih20040916

    (2)20mg:guoyaozhunzih20061220